Mots C rau poob phaus

Mots c rau poob phausyog ib qho me me peptide tsim los ntawm 16 amino acids encoded los ntawm mitochondrial DNA, teej tug mus rau tsev neeg ntawm mitochondrially derived peptides. Nws lub luag haujlwm tseem ceeb yog ua raws li cov txiaj ntsig zoo ntawm cov metabolism hauv lub cev: hauv kev tshawb fawb tsiaj, MOTS-c tau pom tias yuav txhim kho cov piam thaj los ntawm cov leeg pob txha, txhim kho insulin rhiab heev, tiv thaiv siab - noj zaub mov rog- ntxias rog, thiab txhawb kev tawm dag zog lub cev. Tsis zoo li feem ntau qhov hnyav- cov khoom xyaw poob uas lub hom phiaj qab los noj mov lossis kev nqus caloric, MOTS-c ua ncaj qha rau ntawm lub hauv paus hubs ntawm cellular zog metabolism, txhawb kev siv zog ntau dua hauv lub cev.

1.Metabolism thiab tswj qhov hnyav
Rau cov tib neeg muaj kev txhawj xeeb txog kev noj qab haus huv metabolic, thaj chaw txaus siab tshaj plaws ntawm MOTS-c yogkev cai metabolic.
Hauv kev soj ntsuam kev tshawb fawb txog tib neeg cov ntsiab lus, kev tshuaj xyuas thiab kev ntsuas meta- tsom xam suav nrog 602 tus neeg koom tau qhia tias MOTS- qib c hauv cov neeg mob ntshav qab zib tau qis dua cov neeg noj qab haus huv. Qhov kev tshawb pom no qhia tau hais tias MOTS-c txuas nrog rau tus neeg lub cev metabolic.

Qhov tseem ceeb, Phase 2a kev sim tshuaj ntsuam xyuas tam sim no tab tom koom nrog cov neeg laus uas muaj ntshav qab zib uas tseem rog dhau lossis rog; Txoj kev tshawb no yog txhawm rau ntsuas qhov ua tau zoo ntawm 12-lub lim tiam ntawm kev kho MOTS-c hauv kev txhim kho cov tshuaj insulin.

2. Mob plawv
Rau cov neeg saib xyuas kev noj qab haus huv ntawm cov hlab plawv, lub peev xwm ntawm MOTS-c raws li tus neeg saib xyuas cardioprotective warrants tshwj xeeb. Cov kev tshawb fawb soj ntsuam tau pom tias cov ntshav MOTS-c qib tau txo qis hauv cov neeg mob atrial fibrillation, thiab cov qib no pom qhov cuam tshuam tsis zoo nrog sab laug atrial txoj kab uas hla.

Tsis tas li ntawd, tshuaj xyuas cov ntawv qhia tau hais tias MOTS-c muaj peev xwm rau kev siv tshuaj kho mob hauv kev tswj cov kab mob plawv, nrog rau nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam los tiv thaiv- cov teebmeem inflammatory thiab txo cov kev ntxhov siab oxidative.

3.Age-Txoj Kev Noj Qab Haus Huv
Raws li tib neeg lub cev muaj hnub nyoog, qib endogenous ntawm MOTS-c poob lawm. Kev tshawb fawb tau tsim ib qho kev sib txuas ntawm kev txo qis MOTS- qib c thiab qhov tsis zoo ntawm cov kab mob pancreatic islet- cov txheej txheem uas tuaj yeem cuam tshuam cov piam thaj hauv metabolic. Raws li kev xav, kev tswj hwm lossis ntxiv MOTS- qib c tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev ncua sijhawm pib ntawm qee lub hnub nyoog- cuam tshuam txog kev noj qab haus huv.

Tsis tas li ntawd, kev tshuaj xyuas kev tshawb fawb qhia txog qhov muaj peev xwm ntawm MOTS-c hauv kev tawm tsam insulin tsis kam thiab o-ob qhov kev sib tw kev noj qab haus huv uas nquag tshwm sim thaum lub sijhawm laus.

Raws li ib tugmitochondria - tau txais peptidemuaj 16 amino acids, MOTS-c xav tausiab - cov ntaub ntawv zoothiabruaj khov khoom saw hlau tswjthoob plaws nws cov txheej txheem ntau lawm.

Peb tau tsim kev koom tes ntev -kev koom tes nrogGMP{0}} ntawv pov thawjamino acid lwm tus neeg, xyuas kom meej tias txhua batch ntawm raw khoom yogtaug qab tauthiab zoo ib yam. Hais txog kev tsim khoom, peb ntiavsolid-phase peptide synthesisthev naus laus zis, nrog cov txheej txheem kev khiav haujlwm tswj txhua kauj ruam -los ntawmresin xaivthiab amino acid coupling raukawg cleavage thiab purification. Tsis tas li ntawd, MOTS-c lyophilized hmoov yuav tsum muaj kev tiv thaiv los ntawmlub teeb, noo noo, thiab qis -kubtej yam kev mob thaum lub sij hawm cia thiab thauj. Peb tau tsim ibtag nrho txias chain Management systemlos ntawm cov chaw tsim khoom mus rau cov neeg siv kawg, kom ntseeg tau tias cov khoom tseem nyob hauv qhov kev pom zoo thaum tuaj txog.

• Muaj -qib peptide synthesizers nrog ib batch muaj peev xwm los ntawmgram mus rau pua -gram nplai, txhawb nqa ob qho kev sim R & D thiab kev lag luam batch
• Kev npaj HPLCcov txheej txheem rau kev ua kom huv huv, xyuas kom muaj kev tshawb fawb- qib purity qib
• Industrial- nplai khov- ziabcov cuab yeej muaj peev xwm tuav tau ntau yam ntim tshwj xeeb hauv ib pawg
• Cov txheej txheem nruj tswj xyuas kom ntseeg taubatch-rau-batch sib xwsnyob rau hauv purity, molecular hnyav, thiab lwm yam zoo cwj pwm

• Xyoo ntawm kev paub hauvpeptide tsim thiab optimization
• Kev cai synthesis cov kev pabcuam suav nrogkev hloov kho raws qib, cyclization, thiab fluorescent labeling (FITC, biotin, thiab lwm yam)
• Comprehensive analytical txoj kev:HPLC purity tsom xam, huab hwm coj spectrometry molecular luj txheeb xyuas, peptide ntsiab lus txiav txim
• Kev pab txhawb nqa:reconstitution kev taw qhia, cov lus pom zoo cia, kev siv lub voj voog siv
• Kev soj ntsuam tas li ntawm qhov kev tshawb fawb tshiab tshaj plaws nyob rau hauvmitochondria- tau txais peptides

Mots c rau poob phaus lyophilized hmoov yog qhov kub thiab txias - cov khoom tshawb fawb rhiab heev uas yuav tsum muaj qhov ntsuas kub tsawg - ib puag ncig thoob plaws hauv cov txheej txheem xa khoom. Peb siv cov txheej txheem txias saw logistics los xyuas kom meej tias txhua theem ntawm peb lub tsev rau khoom mus rau cov neeg siv khoom txhais tes tseem nyob hauv kev tswj xyuas.

• Kub- tswj kev thauj khoom: Raws li cov qauv kev coj ua rau cov khoom peptide, MOTS-c feem ntau xav tautxias txias ntawm 2-8 degreethaum caij tsheb thauj mus los, thiab qee zaum txawm tias qhov ntsuas kub qis dua yuav xav tau. Peb lub hnab ntim khoom txias tau raug lees paub los tswj qhov kub thiab txias nyob rau hauv cov qauv kev thauj mus los (24-72 teev).

• Kev tiv thaiv poob siab: Cov khoom muaj nyob rau hauvkho mob- qib iav vials, qhwv nrog kev poob siab- nqus cov ntaub ntawv cushioning kom muaj kev tiv thaiv los ntawm kev cuam tshuam lub cev thaum caij tsheb npav. Tag nrho cov khoom ntim tau raug kuaj nruj kom tiv taus kev thauj khoom ib txwm muaj kev vibrations thiab stacking siab.

• Qhov tseem ceeb ntawm lub sijhawm thauj mus los: Peb koom tes nrog ntau tus kws tshaj lij logistics nqa khoom, ua ntej kev xa khoom nrog cov sij hawm xa khoom zoo kom txo tau cov khoom siv sij hawm hauv kev thauj mus los.