Nws siv sijhawm ntev npaum li cas rau Tianeptine Sodium Powder ua haujlwm?

1. Txheej txheem cej luam

Tianeptine Sodium hmoov,raws li atypical tricyclic antidepressant, muaj lub sijhawm pib uas yuav tsum tau nkag siab los ntawm ob qho tib sipharmacokinetic(kev nqus thiab faib cov tshuaj hauv lub cev) thiabpharmacodynamic(lub sij hawm nws yuav siv sij hawm rau cov tshuaj los tsim kho cov nyhuv) kev xav. Cias muab tso, tianeptine sodium yog absorbed sai heev, mus txog lub ncov plasma concentration kwv yees li ib teev tom qab kev tswj qhov ncauj; Txawm li cas los xij, nws cov tshuaj tiv thaiv kev ntxhov siab tag nrho / kev ntxhov siab feem ntau yuav tsum tau siv ob peb hnub mus rau lub lis piam ntawm kev siv tas li kom pom tseeb.

Qhov sib txawv ntawm "kev nqus sai" thiab "kev pib qeeb" yog qhov muaj ntau ntawm cov tshuaj tiv thaiv kev nyuaj siab. Kev nkag siab qhov sib txawv no yog qhov tseem ceeb rau kev siv cov tshuaj no kom raug, tswj kev cia siab rau kev kho mob, thiab txheeb xyuas qhov kev pheej hmoo ntawm kev tsim txom.

2. Pharmacokinetics: Absorption Rate

Tianeptine sodium yogabsorbed sai thiab tagTom qab kev tswj hwm qhov ncauj, ib qho tseem ceeb ntawm nws cov tshuaj pharmacokinetics. Cov ntaub ntawv los ntawm ntau qhov kev tshawb fawb soj ntsuam:

Ib xyoo 2014 randomized tswj kev tshawb fawb luam tawm nyob rau hauv PubMed ntxiv tau lees paub tias tom qab ib koob tshuaj ntawm 12.5 mg tianeptine sodium nyob rau hauv cov txiv neej noj qab haus huv pab dawb, plasma concentration tau kuaj pom nyob rau hauv 0.33 teev (kwv yees 20 feeb) thiab peaked nyob ib ncig ntawm 1 teev tom qab - koob. Qhov no qhia tau hais tias cov tshuaj nkag mus rau hauv cov hlab ntsha sai heev.

Lus ceeb toom: Cov zaub mov qeeb qhov nqus ntawm tianeptine tab sis tsis cuam tshuam rau tag nrho cov nqi nqus (bioavailability tseem tsis hloov). Yog li ntawd, cov lus pom zoo hauv kev kho mob pom zoo kom noj nws ua ntej noj mov kom ruaj khov thiab pom tau tias nqus tau.

3.Pharmacodynamics: Pib ntawm Kev Kho Mob

Txawm hais tias cov tshuaj nqus tau sai, covtag nrho antidepressant / anxiolytic nyhuv tsis tshwm sim tam sim ntawd. Qhov no yuav tsum txawv ntawm qhov kev paub ntawm "qee yam cuam tshuam."

3.1 Pib Qhov Teebmeem Pib (30 feeb mus rau ob peb teev)

• Tsiaj kev tshawb fawb qhia: Hauv kev sim nas, kev coj cwj pwm (piv txwv li, txo lub sij hawm tsis muaj zog hauv kev sim ua luam dej, cov teebmeem anxiolytic) tau pom kwv yees li ntawm30 feebtom qab kev tswj hwm tianeptine, txhawb kev muaj peev xwm ntawm kev cuam tshuam sai sai rau tib neeg.
• Cov ntaub ntawv qhia txog tus neeg siv (yuav tsum tau saib kom ceev faj, tsis yog kev pom zoo kho mob): Raws li qee tus neeg siv lub rooj sib tham hauv online, thaum noj ntawm lub plab khoob, tianeptine sodium ua rau muaj kev xav ntawm "kev puas siab puas ntsws" thiab "txo kev ntxhov siab hauv zej zog" nyob rau hauv kwv yees li.15-20 feeb, nrog cov teebmeem ntev txog2-3 teev. Cov lus piav qhia no ua raws li cov tshuaj tau nrawm nrawm, tab sis cov kev xav no yog cov kev paub dhau los uas muaj feem cuam tshuam rau tam sim ntawd los ntawm mu-opioid receptor activation, es tsis yog tag nrho cov tshuaj tiv thaiv kev nyuaj siab.

3.2 Tsim kom muaj Kev Ua Tau Zoo (Hnub mus rau Lub Limtiam)

Kev tshawb fawb soj ntsuam xaus: Raws li 1995 kev tshuaj xyuas kev tso cai hauvTshuajphau ntawv journal, lubCov tshuaj tiv thaiv kev ntxhov siab thiab cov teebmeem anxiolytic ntawm tianeptine feem ntau tshwm sim tom qab siv tas li rau ob peb hnub mus rau lub lis piam.. Qhov no zoo ib yam nrog rau feem ntau cov tshuaj tiv thaiv kev nyuaj siab-lawv yuav tsum muaj lub sij hawm tsub zuj zuj los ua kom ruaj khov kho los ntawm cov txheej txheem xws li tswj cov neuroplasticity.

(1) Lub sijhawm tshwj xeeb:

• luv-kev kho mob lub sij hawm (4 lub lis piam mus rau 3 lub hlis): Cov kev tshawb fawb soj ntsuam pom tau tias tianeptine piv tau zoo rau cov tshuaj tiv thaiv kev nyuaj siab xws li amitriptyline, imipramine, thiab fluoxetine hauv lub sijhawm no.
• Ntev -kev kho mob ntev (1 xyoos): Cov txiaj ntsig kho mobtxuas ntxiv txhim khonrog rau ntev - siv sijhawm ntev, thiab ntev - kev kho mob yuav txo tau txoj kev pheej hmoo ntawm kev nyuaj siab rov qab los yog rov tshwm sim dua.

(2) Kev sib txawv ntawm tus kheej hauv lub sijhawm pib:

• Cov hluas, cov neeg noj qab nyob zoo: Tej zaum yuav muaj qhov pib sai dua.
• Cov laus: Vim lub neej ntev ib nrab- thiab txo cov peev txheej hauv metabolic, yuav siv sijhawm ntev dua kom ua tiav cov txiaj ntsig ruaj khov, thiab yuav tsum tau txo cov koob tshuaj (ntau tshaj 25 mg / hnub).
• Lub raum insufficiency: Ib nrab ntawm - lub neej ntawm cov thawj metabolite MC5 yog ntev heev (los ntawm kwv yees . 4.9 teev mus rau 14.2 teev), yog li yuav tsum tau hloov koob tshuaj (pom zoo: 12.5 mg ob zaug ib hnub twg), thiab lub sij hawm mus txog khov kho- lub xeev concentrations thiab kev ua tau zoo kuj yuav ntev.

3.3 Cov yam ntxwv ntawm cov nyhuv anxiolytic

Tianeptine yog tshwj xeeb tshaj yog zoo rau kev txhim khopsychic ntxhov siab vim. Ib qho placebo- tswj kev sim tau pom tias hauv cov neeg mob ntxhov siab nrog kev ntxhov siab, tianeptine yog qhov zoo tshaj rau cov placebo hauv kev txo cov kev ntxhov siab ntawm lub hlwb, thiab nws tag nrho cov nyhuv anxiolytic zoo ib yam li amitriptyline, imipramine, thiab fluoxetine. Cov ntaub ntawv tshawb fawb qhia tau hais tias tianeptine tuaj yeem txo cov qhab nia ntawm Hamilton Anxiety Rating Scale (HARS) los ntawm36% mus rau 66%.

4.Key Clinical Use Points

Hauv cov ntsiab lus

Tianeptine sodium qhov pib ua haujlwm muaj ob - theem yam ntxwv:

Kev nqus sai sai: Peak plasma concentration tau mus txog kwv yees li 1 teev tom qab kev tswj hwm, thiab qee cov neeg siv yuav muaj kev tswj hwm kev xav thiab kev ntxhov siab hauv 15-30 feeb.

Clinical efficiency theem: Tag nrho cov tshuaj tiv thaiv kev ntxhov siab / tshuaj tiv thaiv -txoj kev ntxhov siab feem ntau yuav tsum tau siv tas li rau ob peb hnub mus rau lub lis piam kom pom tseeb, thiab ntev -kev kho mob ntev (1 xyoos) tuaj yeem txhim kho cov tsos mob thiab txo qhov kev pheej hmoo rov qab.