Hauv kev tshawb fawb biomedical, vasoactive plab hnyuv peptide (VIP) yog ib qho tseem ceeb ntawm endogenous neuropeptide. Thaum xub thawj pom hauv plab hauv xyoo 1970, kev tshawb fawb tom qab tau qhia tias nws yog qhov dav dav "lub hlwb-gut peptide," ua lub luag haujlwm tseem ceeb hauv ob qho tib si hauv nruab nrab thiab lub paj hlwb peripheral.
Cov kab lus no tsom mus sivVIP 10 mgua piv txwv los piav qhia, los ntawm cov kev tshawb fawb nrov, cov kev tawm tsam ntawm lub cev muaj zog no bioactive peptide tuaj yeem tshwm sim tom qab nkag mus rau tib neeg lub cev, pab cov kws tshaj lij hauv kev lag luam cuam tshuam tsim kev nkag siab txog kev tshawb fawb ntawm cov molecule no.
Mechanism ntawm Action ntawm VIP
Lub active ingredient nyob rau hauvVIP 10 mgyog polypeptide muaj 28 amino acids. Nws cov txheej txheem ntawm kev ua haujlwm zoo ib yam li tus yuam sij qhib qhov tshwj xeeb "locks" ntawm lub xov tooj ntawm tes -namely, VPAC1 thiab VPAC2 receptors. Thaum VIP khi rau cov receptors no, nws ua rau muaj kev hloov pauv ntawm cov teeb liab intracellular, feem ntau cuam tshuam nrog kev nce ntawm tus tub txib thib ob hu ua cyclic adenosine monophosphate (cAMP), uas nyob rau hauv lem tswj downstream signaling pathways xws li protein kinase A (PKA).
Qhov kev khi tshwj xeeb no tso cai rau VIP siv dav thiab meej cov kev cai cuam tshuam rau ntau lub tshuab hauv tib neeg lub cev.
Core Physiological Effects ntawm VIP 10mg
Raws li kev tshawb fawb uas twb muaj lawm, cov teebmeem ntawm lub cev ntawm VIP tom qab nkag mus rau hauv tib neeg lub cev yog qhov tseem ceeb hauv peb qhov tseem ceeb hauv qab no:
1. Cov ntshav ncig thiab cov hlab plawv
Ib qho ntawm cov yam ntxwv tseem ceeb tshaj plaws ntawm VIP yog nws cov txiaj ntsig vasodilatory muaj zog. Nws relaxes cov nqaij leeg ntawm cov hlab ntsha phab ntsa, zoo txo cov hlab ntsha, yog li txhim kho cov ntshav perfusion thoob plaws hauv lub cev, tshwj xeeb tshaj yog nyob rau hauv lub ntsws. Hauv lub ntsws, cov nyhuv no muaj peev xwm tseem ceeb hauv kev txo qis cov hlab ntsha hauv lub ntsws, pab txhim kho qhov cua / perfusion piv thiab txhim kho oxygenation efficiency. Nyob rau tib lub sijhawm, VIP tuaj yeem ua rau kom myocardial contractility, zoo cuam tshuam rau lub plawv ua haujlwm.
2. Immunomodulation thiab Anti-inflammatory Teb
Nyob rau theem tiv thaiv kab mob, VIP tau pom tias yog ib qho tseem ceeb immunomodulator. Nws txo qis cov qib pro- mob cytokines xws li TNF- thiab IL-6, thaum txhim kho kev qhia ntawm cov tshuaj tiv thaiv kab mob xws li IL-10. Los ntawm cov kev cai bidirectional no, VIP pab coj ib tug overactive inflammatory teb rov qab mus rau ib tug balanced lub xeev; Yog li ntawd, VIP yog suav hais tias yog lub hom phiaj muaj txiaj ntsig kev cuam tshuam hauv kev tshawb fawb txog cov kab mob autoimmune thiab cov xeev mob ntev.
3. Digestive System thiab Gastrointestinal Function Regulation
Raws li ib qho ntawm qhov ntxov tshaj plaws neuropeptides pom nyob rau hauv lub plab, VIP plays lub luag haujlwm tseem ceeb hauv kev zom zaub mov. Nws tuaj yeem ua kom cov leeg du ntawm txoj hnyuv, cov kab mob hauv lub cev, thiab qis esophageal sphincter, tswj txoj hnyuv peristalsis atherosclerosis. Tsis tas li ntawd, VIP tuaj yeem txhawb nqa cov txiav ua kom zais cov kua txiv hmab txiv ntoo uas nplua nuj nyob hauv bicarbonate thaum inhibiting gastric acid secretion. Qhov no pab tiv thaiv lub plab hnyuv mucosa thiab tswj cov hnyuv homeostasis.
Cov lus hauv qab no qhia txog lub luag haujlwm tseem ceeb thiab cov txheej txheem ntawm kev ua ntawm VIP hauv ntau lub tshuab:
| Lub Hom Phiaj | Lub ntsiab Physiological teebmeem | Ntsiab Mechanisms of Action |
|---|---|---|
| Cardiovascular System | Vasodilation, txo cov hlab ntshav siab, nce myocardial contractility | khi rau VPAC1 / VPAC2 receptors, relaxes vascular du nqaij |
| Immune System | Inhibition ntawm inflammatory teb, txhawb kev kho mob | Downregulates pro-inflammatory yam (TNF- , IL-6), upregulates anti-inflammatory yam (IL-10) |
| Digestive System | Kev tswj ntawm txoj hnyuv motility, tiv thaiv gastric mucosa, txhawb kev digestive kua txiv secretion | Relaxes du nqaij, inhibits gastric acid secretion, stimulates bicarbonate secretion |
Piv txwv ntawm VIP Daim Ntawv Thov hauv Kev Tshawb Fawb Txog Kev Tshawb Fawb thiab Kev Tshawb Fawb
Tus nqi tsim nyog ntawm VIP tau raug lees paub hauv ntau qhov kev tshawb fawb soj ntsuam nruj. Piv txwv li, nyob rau hauv ob qho tib si - qhov muag tsis pom kev sim ntawm cov txiv neej erectile kawg, kwv yees li 75% ntawm cov neeg kawm tau pom cov lus teb zoo tom qab VIP tau txhaj tshuaj nrog lwm cov tshuaj ntxiv, piv rau qhov ua tau zoo ntawm tsuas yog 12% hauv pawg placebo, nrog cov lus teb ntev li ib teev. Qhov txiaj ntsig no qhia ncaj qha rau kev ua haujlwm ntawm VIP hauv zos vasodilation.
Tsis tas li ntawd, hauv kev tshawb fawb ntawm cov kab mob ntsws hnyav (xws li mob ua pa nyuaj), VIP thiab nws cov analogues tau siv los tshawb txog lub peev xwm los txo cov hlab ntsws thiab txhim kho oxygenation. Hauv thaj tsam ntawm neuroprotection, qee cov kev tshawb fawb kuj tau pom cov nyhuv inhibitory ntawm VIP ntawm neuroinflamation. Cov ntawv thov no yog tag nrho nyob rau hauv kev tshawb fawb lossis cov theem kho mob thaum ntxov thiab tseem tsis tau dhau los ua cov txheej txheem kho mob.
Qhov sib txawv hauv Kev Tshawb Fawb Kev Tshawb Fawb Hauv Kev Sib Txawv Ntawm Cov Ntawv Thov
Nyob ntawm txoj kev ntawm kev tswj hwm thiab kev tshawb fawb lub hom phiaj, qhov tseem ceeb ntawm VIP 10mg siv nws txawv. Cov lus hauv qab no teev ntau cov lus qhia kev tshawb fawb thiab lawv cov ntsiab lus tseem ceeb:
| Kev tshawb fawb teb | Common Route of Administration | Core Focus |
|---|---|---|
| Pulmonary Circulation Research | Nebulized inhalation | Txo cov hlab ntsha pulmonary siab, txo qhov cuam tshuam rau cov ntshav siab |
| Inflamation Regulation Research | Kev txhaj tshuaj hauv zos lossis kev tswj hwm | Tshem tawm cov lus teb hauv zos lossis cov kab mob inflammatory ntau dhau |
| Gastrointestinal Function Research | Local perfusion | Saib xyuas kev hloov pauv hauv peristaltic atherosclerosis thiab qib secretion |
| Kev Tshawb Fawb Neuroprotection | Intrathecal los yog systemic tswj | Inhibit inflammatory signals nyob rau hauv cov ntaub so ntswg neural |
Kev nkag siab tag nrho
Tom qab nkag mus rau tib neeg lub cev,VIP 10 mgkhi rau cov receptors tshwj xeeb uas tau muab faib rau hauv cov hlab ntsha, lub cev tiv thaiv kab mob, thiab kab mob plab, ua rau muaj ntau yam kev hloov pauv ntawm lub cev xws li vasodilation, inflammatory suppression, thiab digestive function regulation. Nws lub ntsiab lus tseem ceeb nyob hauv kev muab cov cuab yeej rau ntau yam - lub hom phiaj kev cai, pab cov kws tshawb fawb kom nkag siab tob txog kev sib cuam tshuam ntawm cov hlab ntshav, tiv thaiv kab mob, thiab plab hnyuv. Kev nkag siab txog cov teebmeem no yuav pab saib VIP lub luag haujlwm hauv kev tshawb fawb txog biomedical ntau dua, tsis yog hais txog nws ua ib qho kev cuam tshuam txog kev ua haujlwm.
Quality guaranteed, npaj npaj, tso koj xaj tam sim no!
Kuv tus email:sales4@lymallpanda.com
WhatsApp: +86 15353955739
