Pure Ergothioneine Powder siv rau dab tsi?

Ntshiab Ergothioneine Powderyogib txwm muaj leej faj- muaj cov amino acidbelongs rau tsev neeg tsawg amino acid. Nws tau ntxim nyiam heev vim nws qhov tshwj xeeb antioxidant zog thiab cell -cov haujlwm tiv thaiv. Tib neeg lub cev tsis tuaj yeem tsim cov ergothioneine thiab yuav tsum tau txais los ntawm kev noj zaub mov lossis tshuaj ntxiv - feem ntau los ntawmnceb(tshwj xeeb tshaj yog cov khoom noj tau zoo xws li nceb oyster, nceb shiitake, thiab nceb enoki),legumes(xws li taum liab thiab taum dub), thiabtsiaj lub siab(xws li nqaij qaib siab thiab nqaij npuas siab). Ergothioneine tus yam ntxwv tshwj xeeb hauv lub cev yog nyob rau hauv nws txoj kev thauj mus los protein ntau OCTN1 (organic cation transporter type 1), uas tso cai rau nws musyuav nquag thauj thiab ua tau zoo nyob rau hauv cov ntaub so ntswg thiab lub cev nrog rau siab oxidative kev nyuaj siab, xws li daim siab (lub ntsiab detoxification lub cev), lub paj hlwb (siab oxygen noj thiab nplua nuj nyob rau hauv lipids), ob lub qhov muag (ntev - lub sij hawm raug rau lub teeb), thiab cov ntshav liab (nruam nqa oxygen). Hauv qhov sib piv, cov tshuaj tiv thaiv antioxidants xws li vitamin C lossis glutathione tsis muaj lub hom phiaj thauj khoom. Nws yog qhov tshwj xeeb tis yam ntxwv uas muab ergothioneine nws muaj peev xwm siv tau hauv ntau qhov chaw, suav nrogneuroprotection, tawv nqaij tiv thaiv- laus, mob plawv, tiv thaiv qhov muag, thiab ncua kev laus ntawm cellular. Cov lus hauv qab no qhia txog nws qhov tseem ceeb siv raws li cov ntaub ntawv tshawb fawb.

1. Muaj txiaj ntsig zoo Antioxidant thiab tiv thaiv -cov khoom muaj zog
Ergothioneine yog ibmuaj zog antioxidant. Cov kev tshawb fawb hauv vitro tau pom tias nws lub peev xwm los tshem tawm hydroxyl radicals (ib hom kab mob uas ua rau muaj kev puas tsuaj loj heev) yog3-5 zauguas ntawm glutathione (Aruoma et al., 1999). Tsis tas li ntawd, ntawm qhov siab ntawm 10-50 µM, ergothioneine cuam tshuam qhov ua kom muaj kev cuam tshuam ntawm txoj kev inflammatory (NF-κB), yog li txo qhov tso tawm ntawm cov tshuaj tiv thaiv kab mob xws li IL-6 thiab IL-8. Qhov no txhais tau tias nws tuaj yeem tshem tawm cov kev puas tsuaj oxidative ncaj qha thiab txo cov lus teb inflammatory ntawm lawv qhov chaw.

2. Neuroprotection thiab kev txawj ntse muaj nuj nqi
Epidemiological cov ntaub ntawv txhawb nqativ thaiv cov teebmeemntawm ergothioneine nyob rau hauvhlwb. Ib txoj kev tshawb fawb uas muaj 568 cov neeg laus pom tias cov neeg uas muaj ntshav siab tshaj plaws ergothioneine muaj kwv yees li 40% qis dua qhov kev pheej hmoo ntawm kev puas siab puas ntsws (MCI) piv rau cov uas muaj qib qis tshaj (Cheah li al., 2016). Hauv cov qauv cellular ntawm tus kab mob Parkinson, kev kho mob nrog 1 mM ergothioneine txo -synuclein (ib qho protein ntau txawv txav) los ntawm 50% thiab tiv thaiv dopaminergic neurons los ntawm kev puas tsuaj rau cov co toxins. Cov ntaub ntawv no qhia tias ergothioneine tuaj yeem muaj peev xwm ua kom qeeb cov kab mob neurodegenerative.

3. Daim tawv nqaij tiv thaiv -Photoaging thiab Whitening
Cov kev tshawb fawb soj ntsuam tau lees paub qhov ua tau zoo ntawm ergothioneine hauv kev tu tawv nqaij. Ib qho randomized, ob npaug - dig muag, tswj kev sim tau pom tias niaj hnub siv lub ntsej muag cream uas muaj 0.1% ergothioneine rau 8 lub lis piam ua rau qhov nruab nrab txo qis ntawm 13.5% hauv melanin Performance index thiab 18.2% erythema Performance index ntawm cov neeg mob daim tawv nqaij, uas yog superior rau tib qhov concentration ntawm min C 0. v, vitamin C. Mechanistically, ergothioneine txo pigmentation los ntawm inhibiting tyrosinase (ib qho tseem ceeb enzyme nyob rau hauv melanin synthesis) thaum tiv thaiv daim tawv nqaij fibroblasts los ntawm DNA puas los ntawm ultraviolet A (UVA).

4. Mob plawv thiab Metabolic Health

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, plasma ergothioneine qib tau kwv yees li 35% qis dua li kev tswj hwm kev noj qab haus huv (P <0.01), thiab cuam tshuam tsis zoo nrog glycated hemoglobin (HbA1c), qhov cim ntawm kev tswj glycemic. Hauv kev tshawb fawb tsiaj, ergothioneine supplementation ntawm koob tshuaj ntawm 5 mg / kg / hnub rau 4 lub lis piam txo aortic intima-media thickness los ntawm 30% thiab malondialdehyde (MDA), lipid peroxidation marker, los ntawm 45% nyob rau hauv nas nyob rau hauv ib tug siab - noj cov rog. Cov txiaj ntsig no qhia tias ergothioneine tuaj yeem pab txo qis oxidative puas rau cov hlab ntsha cuam tshuam nrog metabolic syndrome.

5. Kev Tiv Thaiv Qhov Muag
Cov qib siab ntawm OCTN1 transporter protein tau nthuav tawm hauv tib neeg lub lens thiab retina, tso cai rau ergothioneine concentrations hauv cov ntaub so ntswg mus txog.100 lub sij hawmsiab dua hauv plasma. Cov kev tshawb fawb hauv vitro tau pom tias 100 µM ergothioneine tau inhibited hydrogen peroxide tag nrho -induced apoptosis ntawm lens epithelial cells thiab tiv thaiv retinal pigment epithelial hlwb los ntawm lub teeb xiav puas. Cov ntaub ntawv no txhawb nqa lub peev xwm siv ergothioneine hauv kev tiv thaiv kab mob cataracts thiab hnub nyoog - ntsig txog macular degeneration.

6. Mitochondrial Function thiab Anti-aging

Hauv cov qauv kev laus ntawm tes, ergothioneine tuaj yeem txhim kho mitochondrial zog tsim. Piv txwv li, nyob rau hauv tib neeg fibroblasts dhau mus rau lub xeev senescent, qhov sib ntxiv ntawm ergothioneine nce ATP (lub cell lub zog ncaj qha qhov chaw) ntau lawm los ntawm kwv yees li ob zaug, thiab txo qhov feem ntawm mitochondrial membrane muaj peev xwm vau. Hauv * C. elegans* (cov qauv kev tshawb fawb txog kev laus), ntxiv nrog 10 mM ergothioneine ncua lub neej nruab nrab ntawm kwv yees li 18% thiab ncua hnub nyoog - cuam tshuam txog kev poob ntawm lub cev muaj zog.

Ceev Reference los ntawm cheeb tsam