Khoom Description
Hopantenate Calcium Hmoovyog cov khoom siv raw rau cov tshuaj nootropic hauv nruab nrab paj hlwb, feem ntau yog dawb los yog tawm -cov hmoov dawb. Nws cov qauv tshuaj zoo ib yam li vitamin B5, ua ib qho amide derivative ntawm D-pantothenic acid thiab -aminobutyric acid. Pharmacologically, nws feem ntau txhim kho neurotransmitter tshuav nyiaj li cas los ntawm kev tswj GABA receptors thiab cuam tshuam glutamate metabolism. Nws yog feem ntau siv los txhim kho kev txawj ntse, txo kev ntxhov siab, thiab ua ib qho kev kho mob ntxiv rau cov teeb meem neurological xws li kev tsis txaus siab tsis txaus ntseeg siab (ADHD) thiab kev loj hlob qeeb hauv cov menyuam yaus. Cov khoom no yog hygroscopic thiab yuav tsum tau muab cia rau hauv ib lub thawv ntim rau hauv qhov chaw txias, qhuav.
Kev Tswj Xyuas Zoo
| Cov khoom kuaj | Specification | Kev tshwm sim |
|---|---|---|
| Qhov tshwm sim | Dawb hmoov | Ua raws |
| Solubility | Dawb soluble hauv dej, xyaum insoluble hauv ethanol | Ua raws |
| Kev txheeb xyuas (HPLC Retention Time) | Cov qauv siv sib xws (± 2%) | 5.22 min |
| Kev txheeb xyuas (FTIR Spectrum) | Matches siv spectrum | Ua raws |
| Kev Qhia (Calcium Salt) | Cov tshuaj tiv thaiv zoo rau cov ntsev calcium | Ua raws |
| Kev ntsuam xyuas (HPLC) | Tsawg dua lossis sib npaug li 102.0% | 99.9% |
| Cov ntsiab lus dej (KF) | Tsawg dua lossis sib npaug li 3.5% (w / w) | 3.0% |
| Tus nqi pH | 6.5 - 8.0 (zoo rau aqueous tov) | 7.0 |
Txheej txheem ntau lawm
Cov txheej txheem tsim tawm ntawm Hopantenate Calcium Powder feem ntau koom nrog kev sib txuas ntawm siab -pantothenic acid, ua raws li ntsev- ua cov tshuaj tiv thaiv nrog calcium.
Ib.Core Production Route
1.Kev npaj ntawm Hyperpantopic Acid
- Cov precursor no feem ntau yog npaj los ntawm condensation ntawm pantothenic acid (los yog nws daim ntawv lactone, pantothene) nrog -aminobutyric acid (GABA) los yog glycine.
2. Kev tsim ntsev
- Cov txiaj ntsig hyperpantopic acid yog tom qab ntawd ua rau muaj cov calcium uas (xws li calcium hydroxide) hauv qhov nruab nrab aqueous los tsim calcium hyperpantopicate.
- Cov khoom yog feem ntau tau los ntawm crystallization los ntawm kev daws. Lwm txoj hauv kev tuaj yeem cuam tshuam GABA nrog cov khoom siv calcium (xws li calcium isopropoxide) ua ntej condensation.
2. Txheej txheem txheej txheem
Kauj Ruam 1: Calcium 4-aminobutyric acid yog npaj los ntawm reflux cov tshuaj tiv thaiv ntawm calcium hydroxide nrog 4-aminobutyric acid nyob rau hauv thawj hnyav (piv txwv li, methanol) ntawm 20-65 degree.
Kauj Ruam 2: Cov khoom lag luam los ntawm Kauj Ruam 1 yog qhuav, thiab tom qab ntawd cuam tshuam nrog panthenol hauv qhov hnyav thib ob (xws li isopropanol) ntawm reflux ntawm 50-85℃rau 6-20 teev.
Kauj Ruam 3 (Crystalization): Tom qab cov tshuaj tiv thaiv tiav, hexane ntxiv rau qhov sib tov, ua raws li kev sib xyaw, pom, ntxuav cov khoom nrog hexane, thiab ziab kom tau cov khoom nyoos.
Kauj Ruam 4 (Purification): Cov khoom nyoos yog recrystallized siv cov kuab tshuaj sib xyaw ntawm ethanol thiab hexane kom tau txais cov khoom kawg, siab -calcium pantothenate.
Kev tsim khoom ntawm cov khoom sib xyaw no feem ntau hais txog kev tswj xyuas meej ntawm cov tsis xws li pH, qhov kub thiab txias, thiab reactant concentration kom ntseeg tau tias muaj txiaj ntsig zoo thiab siab purity, ntxiv los ntawm cov kauj ruam xws li pom, ziab, thiab crystallization.
Cov khoom siv
Hopantenate Calcium Powder feem ntau yog siv los txhim kho kev txawj ntse, npog ntau thaj chaw los ntawm kev loj hlob ntawm menyuam yaus mus rau cov kab mob neurodegenerative hauv cov neeg laus.
1.kev siv tseem ceeb
| Qeb qhia | Daim ntawv thov tshwj xeeb | Cov ntaub ntawv tseem ceeb |
|---|---|---|
| Childhood Neurodevelopmental Disorders | Kev Tiv Thaiv Tsis Txaus Siab Hyperactivity Disorder (ADHD), Kev Txhim Kho qeeb | Pab txhim kho kev mloog zoo thiab txo qis hyperactivity thiab impulsive cwj pwm |
| Adult Cognitive Impairment | Cov kab mob neurodegenerative (xws li, Alzheimer's disease), Vascular Dementia, Post-Stroke Cognitive Recovery | Siv los txhim kho kev txawj ntse poob thiab txhawb kev ua haujlwm ntawm lub paj hlwb |
| Mental Retardation | Kev puas siab puas ntsws me me nrog kev cuam tshuam hyperactivity, inattention, thiab hais lus tsis meej | Ib qho piv txwv classic tau sau tseg hauv cov ntaub ntawv ua ntej |
| Tardive Dyskinesia | Kev tsis txaus siab, rov ua dua cov leeg nqaij los ntawm kev siv sijhawm ntev - siv cov tshuaj tiv thaiv kab mob (neuroleptics) | Ib xyoo 1985 kev tshawb fawb soj ntsuam tau pom cov tsos mob tseem ceeb txhim kho tom qab 4-8 lub lis piam ntawm kev kho mob |
2.lwm siv
- Adjunctive Treatment for Cerebral Palsy: Txhawm rau txhim kho kev ua raws li tus neeg mob noj tshuaj, cov cuab yeej patented no ua ke nrog hyperpantothenate calcium nrog -cyclodextrin los npog lub iab saj.
- Kev tswj hwm ntawm Neuroendocrine: Cov kev tshawb fawb tsiaj thaum ntxov tau pom cov tshuaj cuam tshuam rau kev tso tawm cov tshuaj hormones, xws li nws cov txiaj ntsig ntawm kev tso tawm thyrotropin- tso cov tshuaj hormones (TRH) los ntawm cov qog adrenal ntawm nas, qhia tias hyperpantothenate calcium tuaj yeem koom nrog hauv kev tswj hwm neuroendocrine.
- Txhim kho kev qaug zog, pw tsaug zog, thiab teeb meem kev xav: Qee cov ntaub ntawv hais txog cov tshuaj muaj peev xwm txo tau kev ntxhov siab, txhim kho kev pw tsaug zog, thiab txo qis kev ntxhov siab, uas cuam tshuam nrog nws cov txheej txheem tseem ceeb ntawm kev tswj hwm GABAergic system, ua rau sedative thiab mus ob peb vas -stabilizing teebmeem los ntawm kev txhim kho inhibitory neurotransmission.
Zuag qhia tag nrho, txhua daim ntawv thov ntawm calcium perpanitate tig mus ncig ib qho tseem ceeb:tswj kev ua haujlwm ntawm lub hauv nruab nrab paj hlwb. Txawm hais tias kho cov teeb meem neuropsychiatric (xws li ADHD, dementia, thiab tardive dyskinesia) lossis tshawb nrhiav kev tiv thaiv kab mob, kev tswj hwm endocrine, thiab kev txhim kho lub siab, lub hauv paus txheej txheem cuam tshuam nrog nws lub luag haujlwm ua GABA-B receptor agonist hauv kev tswj qhov sib npaug ntawm neural excitation thiab inhibition.
FAQ
Q: Vim li cas cov tshuaj pheej hmoo siab dua rau cov menyuam yaus?
A: Cov ntaub ntawv kho mob tam sim no qhia tau tias muaj kev cuam tshuam loj heev xws li Reye's syndrome feem ntau yog tsom rau cov neeg mob hauv cov menyuam yaus ntawm cov tshuaj ntev -. Yog li ntawd, cov tshuaj rau cov me nyuam yuav tsum tau ua raws li kev saib xyuas nruj ntawm tus kws kho mob tshwj xeeb, thiab cov niam txiv raug txwv tsis pub siv tshuaj rau lawv tus kheej.
Q: Cov ntsuas twg yuav tsum tau saib xyuas thaum noj tshuaj?
A: 1.Cov qib ammonia ntshav: ceeb toom rau qhov tshwm sim ntawm hyperammonemia. 2. Cov cim qhia txog kev ua haujlwm hauv siab: Saib xyuas cov kev hloov pauv hauv daim siab enzymes, thiab lwm yam. 3. Cov kab mob hauv paj hlwb: Saib xyuas qhov txawv txav ntawm kev nco qab, kev coj cwj pwm, thiab lub cev muaj zog.
Q: Cov tsos mob dab tsi xav tau kev kho mob tam sim?
A: 1.Ua tsis taus, ntuav hnyav 2.Tsis meej pem, tsaug zog nrog kev nyuaj waking, los yog tus cwj pwm txawv txav 3.Seizures los yog convulsions 4.Service tsis muaj zog, ua pa ceev, thiab lwm yam cim ntawm metabolic cuam tshuam.
Cim npe nrov: Hopantenate calcium hmoov, Tuam Tshoj hopantenate calcium hmoov manufacturers, lwm tus neeg, Hoobkas
