Vim li cas thiaj tsim nyog txhaj tshuaj?
Glutathione, tsim los ntawm cov amino acids glutamate, cysteine, thiab glycine, yog qhov tseem ceeb tshaj plaws endogenous antioxidant hauv tib neeg lub hlwb. Nws cov haujlwm tseem ceeb ntawm lub cev muaj xws li:
Tshem tawm cov dawb radicals: Ncaj nraim neutralizing reactive oxygen hom xws li hydrogen peroxide, superoxide anions, thiab hydroxyl radicals, tiv thaiv cell membranes thiab DNA los ntawm oxidative puas.
Tuav lub cev tiv thaiv kab mob ua haujlwm: Cov haujlwm ntawm lymphocytes thiab macrophages yog nyob ntawm cov qib glutathione intracellular; ib qho khoom noj txaus yog qhov yuav tsum tau ua ua ntej rau kev tiv thaiv kab mob.
Kev koom tes hauv cov metabolism hauv cov coxin: Raws li cov cofactor ntawm glutathione S-transferase (GST), nws catalyzes kev khi ntawm ntau yam exogenous co toxins (xws li tshuaj metabolites thiab ib puag ncig muaj kuab paug) nrog glutathione, tsim dej- soluble conjugates uas tom qab ntawd tawm los ntawm cov zis los yog tso zis.
Raws li kev sau npe tshuaj thiab kev kho mob hauv ntau lub tebchaws,Glutathione 1500 mgFeem ntau yog siv nyob rau hauv cov kev kho mob hauv qab no scenarios:
| Qeb qhia | Tej yam xwm txheej/Kev siv | Pom zoo noj thiab Hoob kawm | Txoj kev tswj hwm |
|---|---|---|---|
| Tshuaj Kho Mob/Radiotherapy Adjuvant | Kev txo qis ntawm nephrotoxicity, neurotoxicity, thiab myelosuppression tshwm sim los ntawm chemotherapeutic agents xws li cisplatin thiab cyclophosphamide; txo cov hluav taws xob-induced mucositis | Thawj koob tshuaj: 1.5g / m², yaj nyob rau hauv 100ml ib txwm saline, infusion intravenous tshaj 15 feeb; rau cov neeg mob siv hluav taws xob kho mob, muab tshuaj tom qab irradiation ntawm tib koob tshuaj | Cov tshuaj infusion |
| Hepatic Disease Adjuvant Therapy | Viral kab mob siab (hom A, B, C), kab mob siab hnyav, kab mob siab cawv, tshuaj- ua rau lub siab raug mob, daim siab rog, daim siab mob siab | Cov kab mob siab hnyav: 1200-2400mg / hnub, tso dej tawm, 30 hnub raws li kev kawm; Alcoholic kab mob siab: 1800mg / hnub, tso dej tawm, 14-30 hnub | Intravenous drip |
| Hypoxemia | Mob ntshav qab zib mellitus, Tus neeg laus ua pa nyuaj siab Syndrome (ARDS), mob ischemic cerebrovascular kab mob | Kev tswj hwm ntawm 1.5g / m², yaj hauv 100ml ib txwm saline, infusion infusion | Cov tshuaj infusion |
| Ophthalmology Adjuvant Therapy | Corneal ulcers, corneal endothelial raug mob, kho tom qab phais mob cataract | 1500mg ntxiv rau 500ml infusion tov, intravenous drip | Intravenous drip |
| Dermatological Adjuvant Therapy | Allergic purpura, mob urticaria, postherpetic neuralgia | 1500mg / hnub, tso dej rau hauv cov hlab ntsha, lub sijhawm kawm nyob ntawm tus mob | Intravenous drip |
Ua kom tiav Infusion txheej txheem rau 1500mg Specification
Kev tswj hwm ntawm lubGlutathione 1500 mg Muaj plaub theem tseem ceeb: kev npaj, dilution, infusion, thiab saib xyuas. Txhua kauj ruam yuav tsum muaj kev tuav haujlwm.
| Kauj Ruam | Cov ntsiab lus tshwj xeeb thiab tsis muaj |
|---|---|
| Kev npaj | Dissolve 1500mg lyophilized hmoov nyob rau hauv 10ml ntawm sterile dej rau txhaj los yog ib txwm saline. Maj mam swirl kom txog thaum yaj tag, yielding ib tug ntshiab tov nrog ib tug concentration ntawm kwv yees li 150mg / ml. |
| Dilution | Ntxiv cov tshuaj saum toj no rau 100-250ml ntawm ib txwm saline los yog 5% dextrose tov (siv 100ml rau kev kho tshuaj kho mob adjuvant; siv 250-500ml rau kev kho mob siab). |
| Infusion tus nqi | Tswj cov dej ntws ntawm 30-40 tee ib feeb; tag nrho cov sij hawm infusion yog li ntawm 15 feeb mus rau 2 teev (15 feeb rau kev kho mob chemotherapy adjuvant, 1-2 teev rau kev kho mob siab). |
| Lub sijhawm Infusion | Chemotherapy adjuvant: ua kom tiav cov tshuaj tsis pub dhau 15 feeb ua ntej siv tshuaj khomob; Kev kho kab mob siab: infuse ntawm lub sijhawm teem tseg txhua hnub. |
| Tag Nrho -Course Monitoring | Saib xyuas cov ntshav siab, lub plawv dhia, ua pa, thiab cov tawv nqaij tshwm sim thoob plaws hauv qhov dej; muaj cov tshuaj kho mob xwm txheej ceev xws li epinephrine thiab corticosteroids yooj yim. |
| Sijhawm txwv rau kev siv | Siv tam sim ntawd tom qab dissolution; yog tias tsim nyog khaws cia ib ntus, tso rau hauv tub yees ntawm 2-8℃tsis pub ntau tshaj 8 teev. |
Kev txwv nruj:
Kev txhaj tshuaj bolus nrawm nrawm yog txwv nruj heev - kev txhaj tshuaj sai heev yog thawj qhov ua rau hypotension, palpitations, lub ntsej muag flushing, thiab kiv taub hau.
Tsis txhob sib xyaw nrog lwm cov tshuaj hauv tib lub raj mis infusion - tshwj xeeb tshaj yog Vitamin K3, Vitamin B12, calcium pantothenate, antihistamines, ntev - ua sulfonamides, tetracyclines, Promethazine, Papaverine, thiab lwm yam.
Vim li cas thiaj xaiv txhaj tshuaj rau qhov ncauj?
Qhov ncauj glutathione yuav tsum tau nkag mus rau hauv lub plab zom mov, qhov twg plab acid thiab plab hnyuv peptidase zom nws mus rau hauv ib qho loj ntawm cov amino acids dawb. Tsuas yog ib feem pua tsawg tau nqus mus rau hauv cov hlab ntsha ua tiav tripeptide (bioavailability kwv yees li 10-20%). Hauv qhov sib piv, kev txhaj tshuaj tso cai rau nws nkag mus rau hauv cov hlab ntsha ncaj qha, ua tiav 100% bioavailability thiab nce cov ntshav plasma thiab cov ntaub so ntswg glutathione sai sai hauv feeb- tus nqi hloov tsis tau raws sij hawm- cov xwm txheej kho mob zoo xws li tshuaj tua kab mob toxicity tiv thaiv thiab mob siab mob.
1500mg Injectable vs. Qhov ncauj Glutathione
| Sib piv Dimension | Glutathione 1500 mg | Qhov ncauj Glutathione Supplements |
|---|---|---|
| Kev faib khoom | Cov tshuaj noj, yuav tsum tau ib tug kws kho mob cov tshuaj | Kev noj zaub mov ntxiv (dhau - lub- txee) |
| Kev siv | Tsev kho mob, muaj ntawv tso cai kho mob lub tsev kho mob | Txhua qhov chaw xws li tsev, chaw ua haujlwm, thiab lwm yam. |
| Tus thawj tswj hwm | Tus kws kho mob sau cov txheej txheem; tus nais maum tswj kev txhaj tshuaj | Tus kheej- tswj hwm los ntawm tus neeg siv |
| Bioavailability | 100% | 10–20% |
| Pib ntawm Action | Hauv feeb | Kaum feeb mus rau ob peb teev |
| Ntshav siab | Precisely tswj tau | Uncontrollable, fluctuates heev |
| Hom Ib Dose | 1500-2500mg (raws li qhov chaw ntawm lub cev) | 100-500 mg |
| Lub Hom Phiaj | Cov neeg mob kho mob hauv tsev kho mob lossis sab nraud | Feem ntau cov neeg noj qab nyob zoo |
| Lub Hom Phiaj | Kev kho mob (chemotherapy adjuvant, kab mob siab, thiab lwm yam) | Kev saib xyuas antioxidant txhua hnub |
| Risk Level | Siab (yuav tsum tau npaj kev npaj xwm txheej ceev) | Tsawg (qee zaus mob plab hnyuv tsis xis nyob) |
| Regulatory Level | Kev tso cai sau npe tshuaj hauv tebchaws | Dietary supplement filing/registration |
| Kev tswj hwm tus kheej - Tso cai? | Tsis yog kiag li | Tej zaum yuav raug coj los ntawm nws tus kheej raws li cov lus qhia ntawm daim ntawv lo |
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