oxytocin peptide siv sijhawm ntev npaum li cas los ncaws hauv?

Oxytocin Peptide hmoovyog nonapeptide hormone synthesized los ntawm hypothalamus thiab khaws cia rau hauv neurohypophysis. Nws plays ntau lub luag haujlwm hauv tib neeg lub cev, suav nrog kev yug menyuam, lactation, kev coj tus cwj pwm, thiab kev tswj kom zoo. Nrog rau kev nce qib ntawm kev tshawb fawb hauv xyoo tas los no, oxytocin tau txais kev saib xyuas ntxiv los txhim kho kev ntxhov siab hauv zej zog thiab txhawb kev sib raug zoo.

Oxytocin yog ib hom tshuaj polypeptide uas feem ntau siv nws cov teebmeem los ntawm kev khi rau oxytocin receptors ntawm lub hom phiaj hlwb. Nws cov teebmeem physiological classic suav nrog:

1. Uterine Contraction: Oxytocin stimulates uterine smooth nqaij contractions. Cov nyhuv no maj mam nce thaum cev xeeb tub, peaking ntawm lub sij hawm. Clinically, nws yog siv rau induction ntawm lub zog, zog stimulation, thiab kev tiv thaiv ntawm postpartum hemorrhage.

2. Lactation Promotion: Oxytocin stimulates lub contraction ntawm myoepithelial hlwb nyob ib ncig ntawm mammary alveoli, txhawb cov kua mis tshem tawm ntawm cov qog mammary, tab sis tsis cuam tshuam rau cov kua mis secreted.

3. Central Nervous System cuam tshuam: Oxytocin ua rau thaj chaw ntawm lub hlwb xws li amygdala thiab prefrontal cortex, tswj kev coj tus cwj pwm, kev sib txuas ntawm kev xav, thiab kev paub txog kev xav. Cov txheej txheem no ua rau nws lub hom phiaj tseem ceeb rau kev tshawb fawb txog kev sib raug zoo, kev ntxhov siab, thiab kev coj cwj pwm.

Lub sijhawm pib ntawm oxytocin sib txawv heev nyob ntawm txoj kev tswj hwm. Hauv qab no yog cov ncauj lus kom ntxaws sib piv:

Intravenous thiab intramuscular txhaj tshuaj
Intravenous txhaj yog txoj kev siv feem ntau hauv cov chaw kho mob. Nws qhov txiaj ntsig yog nyob rau hauv kev tswj hwm koob tshuaj thiab muaj peev xwm txiav tawm kev tswj hwm sai yog tias muaj kev phiv tshwm sim. Tom qab txhaj tshuaj IV, oxytocin yuav siv tau tam sim ntawd, tab sis nws cov ntshav ib nrab - lub neej luv heev - tsuas yog 1-6 feeb - raws li oxytocinase hauv cov ntshav sai sai inactivates nws.

Kev txhaj tshuaj intramuscular muaj lub sijhawm pib ntawm 3-5 feeb, nrog cov teebmeem ntev 30-60 feeb. Nws yog feem ntau siv los tiv thaiv postpartum hemorrhage tom qab tus me nyuam placental.

Nasal Spray
Cov tshuaj tsuag qhov ntswg tam sim no yog daim ntawv siv ntau tshaj plaws uas siv tsis yog - kho mob. Lub qhov ntswg mucosa yog nplua nuj nyob rau hauv cov hlab ntsha hauv qab nws qhov chaw, thiab nws qhov sib thooj rau txoj kev olfactory muab ib txoj kev ncaj qha rau oxytocin nkag mus rau hauv nruab nrab lub paj hlwb.

Cov lus ceeb toom txog lub sijhawm pib ntawm qhov ntswg qhov ntswg sib txawv: qee cov khoom lag luam thov cov teebmeem tuaj yeem hnov ​​​​hauv 5 feeb, thaum cov kev tshawb fawb soj ntsuam feem ntau tshaj tawm qhov pib ntawm 30-45 feeb. Cov kev tsis sib xws no yuav muaj feem cuam tshuam rau tus kheej rhiab heev, cov qauv tsim tshwj xeeb, thiab qhov sib txawv ntawm cov txiaj ntsig ntsuas. Cov teebmeem feem ntau kav li 1-4 teev.

Qhov ncauj Formulations
Qhov ncauj oxytocin raug rhuav tshem sai sai los ntawm trypsin hauv plab hnyuv thiab yog li tsis muaj txiaj ntsig thaum nqos. Yog li ntawd, cov khoom lag luam ntawm qhov ncauj feem ntau yog cov ntsiav tshuaj los yog cov ntsiav tshuaj sublingual (feem ntau hu ua "oxytocin lollipops"), uas tau nqus los ntawm qhov ncauj mucosa. Lub sij hawm kom siab tshaj plasma concentration yog kwv yees li 30 feeb.

1. Cov tshuaj txhaj tshuaj

Xws li Syntocinon (oxytocin txhaj), qhov no yog ib qho tshuaj uas tau pom zoo los ntawm txoj cai tswjfwm cov tshuaj siv rau hauv kev kho mob rau kev ua haujlwm, txhawb kev ua haujlwm, thiab tsis txhob mob ntshav qab zib. Cov khoom no yuav tsum tau siv raws li kev qhia ntawm tus kws kho mob thiab yuav tsum tsis txhob yuav lossis siv yam tsis muaj kev saib xyuas kho mob.

2. Kev tshawb fawb-Qib Peptide Powder
Oxytocin peptide hmoov yog muab rau hauv daim ntawv lyophilized, nrog rau kev purity feem ntau ntau dua los yog sib npaug rau 95%, thiab yuav tsum tau ntev - lub sij hawm cia ntawm -20℃. Cov khoom no tau sau meej meej "Rau kev tshawb fawb siv nkaus xwb, tsis yog siv rau tib neeg lossis tsiaj." Cov neeg siv khoom uas yuav thiab npaj cov khoom no lawv tus kheej ntsib kev pheej hmoo nyab xeeb loj.

3. Nasal Sprays (Kev npaj ua ke)
Oxytocin tshuaj tsuag qhov ntswg muaj nyob nrog kws kho mob cov tshuaj hauv qee lub tebchaws thiab cheeb tsam rau lub hom phiaj xws li txhawb kev sib raug zoo thiab txo kev ntxhov siab hauv zej zog. Nws yuav tsum raug sau tseg tias txoj cai tswjfwm ntawm cov khoom no txawv ntawm ntau thaj tsam, thiab qee qhov tuaj yeem tshwm sim los ntawm kev tsis raug cai.

1. Contraindications (Qhov xwm txheej uas siv yog txwv tsis pub kiag li)

Oxytocin yog contraindicated nyob rau hauv cov neeg hauv qab no:

• Cov neeg tsis haum rau oxytocin los yog ib qho ntawm nws cov excipients
• Cov neeg uas muaj kab mob plawv hnyav lossis lub sijhawm QT ntev
• Cov tam sim no siv prostaglandin analogues (nrog rau ncua sijhawm tsawg kawg 6 teev)
• Cov neeg uas muaj keeb kwm ntawm kev phais uterine (piv txwv li, seemarean) yuav tsum tau ua tib zoo soj ntsuam

2. Kev ceev faj rau cov neeg tshwj xeeb

• Cov poj niam cev xeeb tub: Oxytocin tsuas yog siv rau kev kho mob induction ntawm kev ua hauj lwm nyob rau hauv lub sij hawm cev xeeb tub thiab yuav tsum tsis txhob siv rau non{0}} qhia lub hom phiaj nyob rau hauv thawj los yog thib ob peb lub hlis twg.
• Cov neeg mob ntshav siab / mob plawv: Yog siv tau, yuav tsum tau txo kom tsawg.
• Cov neeg mob uas muaj kab mob siab lossis lub raum tsis txaus: Oxytocin yog metabolized los ntawm daim siab thiab ob lub raum; yuav tsum tau kuaj xyuas tus kws kho mob.